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[DOI] [PubMed] [Google Scholar] 15.Sikiric P., Seiwerth S., Rucman R., Turkovic B., Brcic L., Sever M., Klicek R., Radic B., Drmic D., Ilic S., et al

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This perspective explains why early ER–mitochondria Ca 2+ maladaptation, later lysosomal-autophagic failure, redox amplification, inflammasome activation, and cell-fate decisions are mechanistically linked, and it generates testable predictions about temporal ordering, reversibility, and disease-stage specificity of contact-site remodeling