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Dopachrome can be spontaneously converted to 5,6-dihydroxyindole or enzymatically converted to 5,6-dihydroxyindole-2-carboxylic acid by the other key enzyme of melanogenesis pathway – tyrosinase-related protein 2 (Tyrp2 or DCT)

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CYP4A11 polymorphism correlates with coronary endothelial dysfunction in patients with coronary artery disease—the ENCORE Trials