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FGF21 binds to the heavy and light chains of ferritin, thereby reducing its excessive degradation via the proteasomal and lysosomal autophagic pathways in diabetic cardiomyopathy, causing diabetic cardiomyopathy [100]

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The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used to develop a flow diagram of the selection criteria for reproducibility (Figure 2) [17]