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We stated that making this change retroactively would provide greater clarity for ACOs by establishing continuity in resource language between performance year 2025 and subsequent performance years, allowing ACOs to plan ahead and have additional time to update internal operations and more easily prepare for consistent quality performance standards

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I/R injury is not merely the consequence of the initial ischemic insult but arises from a complex cascade of biochemical and inflammatory processes triggered upon restoration of oxygenated blood flow