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(2017) suggested that hydrogen peroxide-inducible clone-5 (Hic-5) may be crucial for c-Met signaling pathways and HCC metastasis because it mediates HGF-induced reactive oxygen species (ROS)-JNK-signaling pathways in HCC (Wu et al., 2015) and may be also a specific and safe target for treating HCC patients

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The pharmacodynamics of NNMT inhibition may not scale linearly, and target tissue concentrations are unmeasured in humans at any dose