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Lutz Jermutus, who leads the team at AstraZeneca focused on metabolic diseases, downplays that effect and says the company isn’t looking to turn the drug toward weight loss right away

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5-Amino-1MQ operates as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme central to regulating nicotinamide metabolism and intracellular NAD+ levels

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